Causes Of Grover’s Disease: Its Symptoms And Treatment Options

Grover’s disease is a skin disease characterized by appearance of papules particularly on chest and back. Middle aged males are more likely to develop Grover’s disease. Women and children are less likely to get affected with Grover’s disease. Symptoms last from few months to year. It is also known as transient acantholytic dermatosis.

The exact cause of Grover’s disease is not known. Certain factors trigger Grover’s disease. These are:

  • Exposure to sunlight and ultraviolet radiation. Heat and sweat are aggravating factors.
  • Grover’s disease is associated with atopic dermatitis, xerosis cutis and contact dermatitis.
  • Advanced kidney diseases and haemodialysis may trigger Grover’s disease.
  • It can be associated with malignancy.
  • Certain medication such as sulfadoxine- pyrimethamin, ribavirin may trigger Grover’s disease.
  • Grover’s disease is sometimes associated with viral or bacterial infection.

Grover’s Disease Symptoms

Grover’s disease starts suddenly especially in winter season. Red papules can be seen on the chest and back of the affected person. There is a severe itching which causes discomfort.  Symptoms appear after patient is exposed to heat or after sweating.

Most often rash appears on the center of the back and middle part of chest. Sometimes eruptions are seen on arms, thighs and lower sternum. Papules or papulovesicles are seen with excoriation. There will be acantholysis with or without dyskeratosis.

Occasionally there is no itching or there is absence of conspicuous rash. Sometimes associated oral lesions can be present which look like apthae. Usually scalp, hands and soles remain unaffected. Rash may last up to one year and may recur.

Treatment Options For Grover’s Disease

Diagnosis is done by visual inspection of the rash. Skin biopsy is carried out to confirm the diagnosis. Affected tissue will show acntholysis with or without dyskeratosis under the microscope. Spongiosis is commonly observed. Sometimes rounded skin cells are seen.

  • Mild cases are treated with local application of cortisone cream.
  • If itching is severe medication is given to relieve itching.
  • In severe cases antifungal pills or cortisone injections are given. PUVA phototherapy is used when medication fails to give any relief.
  • Avoid wearing tight clothing. Avoid polyester or nylon clothing. Wear clothes made of cotton.
  • Remain in cool places to avoid sweating.
  • Avoid sudden changes in temperature.
  • Avoid exposure to sun.
  • Apply moisturizer to the skin after bathing and at bedtime to prevent dryness of the skin. Aloe vera gel can be used to serve the purpose.
  • Drink plenty of water to keep yourself well hydrated.
  • Boil Margosa (Azadirachta indica) leaves in water for twenty minutes, strain the water and let it cool down. Apply this water on the affected skin. This will give relief from itching.
  • Meditation and relaxation techniques will lessen the stress and will help to reduce the symptoms.
  • Pranayam and mudra have been proved to be beneficial in some cases.
  • Homeopathy can help in Grover’s disease. Detail history and repertorization of case will help to give accurate medicine.
  • One can also take help of energy healing.

1 comment


  1. Effie

    I was diagnosed seven years ago with Grover disease after biopsy. Since then I tried cortisone creams, cold showers and ice cubes on the affected area (in my left back and under my chest) but with temporary relief. Sometimes itching is very bad but I try to keep my skin moisturized by using pure aloe vera gel to soothe the affected area.

    I have noticed that my problem arises only during the summer when temperature is over 35 deg. C as I live in a warm place. During the winter it disappears, but then it comes back in summer exactly in the same parts of my body. I am very much depressed to this problem.

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